ANTICHROMATIN ANTIBODIES
Test:
468
CPT:
86235
Synonyms
1-Antibodies to LE Cell Phenomenon
Special Instructions
Expected Turnaround Time
1 – 3 days
Specimen Requirements
Specimen
1 – 3 days
Volume
1 Ml
Minimum Volume
0.5 mL (Note: This volume does not allow for repeat testing.)
Container
Gel-barrier tube or red-top tube
Collection
If tube other than gel-barrier tube is used, transfer the separated serum to a plastic transport tube.
Storage Instructions
Room temperature
Causes for Rejection
Hemolysis
Test Details
Use
Help to diagnose drug-induced lupus (DIL) and systemic lupus erythematosus (SLE). Antibodies to both chromatin and histones have been found in patients with procainamide-induced lupus; however, patients with lupus induced by drugs such as quinidine, penicillamine, methyldopa, and acebutolol have antibodies to chromatin but not antihistone. Antichromatin antibodies are found in 50% to 90% of SLE patients and have been linked with proteinuria in SLE patients.